SARS-CoV-2 actively destroys macrophages and dendritic cells or reprograms them to the point of being unrecognizable. The COVID-19-overexpressed clusters are highly enriched for genes that define lung structural cell types including epithelial type I, type II, and lymphatic endothelial cells. There is also increased expression for genes related to intercellular or extracellular adhesion compared to controls, as well as additional genes in those categories not normally expressed in those cell types. The ACE2-correlated differentially expressed genes define macrophage and dendritic cells, which are uniformly absent in the COVID-19 samples