Nonstructural protein 11

Nsp11 is a short peptide (13 a.a.) and is cleaved from both polyproteins pp1a and pp1ab. In SARS-CoV-1 nsp11 has been implicated in RNA synthesis. SARS-CoV-2 nsp11 has 85% sequence identity to SARS-CoV-1 nsp11.

Narrative

Nsp11 is a short protein only 13 a.a. in length and is translated from both polyproteins ORF1a and ORF1ab. In SARS-CoV-1 nsp11 has been implicated in RNA synthesis (Su et al. 2006). SARS-CoV-2 nsp11 has 85% sequence identity to SARS-CoV-1 nsp11, with two substitutions between them (Ser⁵Gln and Thr⁶Ser).